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Transplantation Immunology: Methods and Protocols

Transplantation Immunology: Methods and Protocols

Paperback

Series: Methods in Molecular Biology, Book 333

Medical Reference

ISBN10: 1617376329
ISBN13: 9781617376320
Publisher: Springer Nature
Published: Dec 1 2010
Pages: 430
Weight: 1.29
Height: 0.89 Width: 6.00 Depth: 9.00
Language: English
Leading clinicians and scientists in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The area of tolerance induction and reprogramming of the immune system is also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection.

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