Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Translational Research Methods for Tauopathies

Translational Research Methods for Tauopathies

Fortin, Jessica S.

Hardcover

Series: Neuromethods, Book 233

Cognition

ISBN10: 1071652338
ISBN13: 9781071652336
Publisher: Humana
Published: Jul 18 2026
Pages: 300
Weight: 1.65
Height: 0.87 Width: 7.35 Depth: 10.03
Language: English
This volume provides the novice to expert tau scientist with detailed protocols to establish in vitro and in vivo techniques designed for understanding the physiopathology of tau in neurodegenerative diseases. The protocols in this book were intentionally selected to provide a basis for research laboratories focusing on tau neurodegenerative drug discovery, and are organized into four cohesive parts. Part One covers the procuration of recombinant tau protein, which is necessary to produce a particular isoform, induce hyperphosphorylation state, or capture oligomer conformation. Part Two describes techniques to obtain neurofibrillary tangles (insoluble tau) and soluble form of tau. Part Three focuses on conditions mimicking neurodegenerative scenarios in vitro such as oligomer formation, tau-RNA interaction, and seeding. Part Four provides protocols for robust proof of concept studies involving C. elegans, Drosophila, zebrafish, and rodent tau models. This book is part of the established Neuromethods book series, and each chapter includes short introduction to the topic, list of materials, laboratory protocol, recommendations, and troubleshooting section.

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