Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Third Generation Egfr Inhibitors: Overcoming Egfr Resistance and Toxicity Problems

Third Generation Egfr Inhibitors: Overcoming Egfr Resistance and Toxicity Problems

Patel, Harun M.
Pawara, Rahul
Surana, Sanjay J.

Paperback

Medical ReferenceChemistry

ISBN10: 0081026617
ISBN13: 9780081026618
Publisher: Elsevier
Published: Dec 3 2018
Pages: 208
Weight: 0.63
Height: 0.44 Width: 6.00 Depth: 9.00
Language: English

Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends.

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