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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
The Protein Folding Problem and Tertiary Structure Prediction

The Protein Folding Problem and Tertiary Structure Prediction

Legrand, Scott M.
Merz, Kenneth M. Jr.

Paperback

Medical ReferenceBiologyGeneral Gardening

ISBN10: 1468468332
ISBN13: 9781468468335
Publisher: Birkhauser
Published: Apr 2 2012
Pages: 581
Weight: 1.81
Height: 1.21 Width: 6.14 Depth: 9.21
Language: English
A solution to the protein folding problem has eluded researchers for more than 30 years. The stakes are high. Such a solution will make 40,000 more tertiary structures available for immediate study by translating the DNA sequence information in the sequence databases into three-dimensional protein structures. This translation will be indispensable for the analy- sis of results from the Human Genome Project, de novo protein design, and many other areas of biotechnological research. Finally, an in-depth study of the rules of protein folding should provide vital clues to the protein fold- ing process. The search for these rules is therefore an important objective for theoretical molecular biology. Both experimental and theoretical ap- proaches have been used in the search for a solution, with many promising results but no general solution. In recent years, there has been an exponen- tial increase in the power of computers. This has triggered an incredible outburst of theoretical approaches to solving the protein folding problem ranging from molecular dynamics-based studies of proteins in solution to the actual prediction of protein structures from first principles. This volume attempts to present a concise overview of these advances. Adrian Roitberg and Ron Elber describe the locally enhanced sam- pling/simulated annealing conformational search algorithm (Chapter 1), which is potentially useful for the rapid conformational search of larger molecular systems.

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