Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Tumour Hypoxia: Molecular Mechanisms and Clinical Implications

Tumour Hypoxia: Molecular Mechanisms and Clinical Implications

Pastorekova, Silvia
Kopacek, Juraj
Veda

Hardcover

Series: Spectrum Slovakia, Book 1

Medical Reference

Currently unavailable to order

ISBN10: 3631639910
ISBN13: 9783631639917
Publisher: Peter Lang
Published: Nov 15 2012
Pages: 556
Weight: 2.31
Height: 1.07 Width: 6.77 Depth: 9.54
Language: English
Insufficient supply of oxygen, i.e. hypoxia, typically occurs in a broad range of solid tumours due to aberrant vasculature. It is a key component of tumour microenvironment that affects many biological processes at molecular, cellular and tissue levels. Adaptive responses to oxygen deficiency shape signal transduction, cell metabolism, proliferation, differentiation, survival, angiogenesis, immunosurveillance etc. and thereby contribute to tumour invasion and metastasis. Presence of tumour hypoxia is significantly associated with poor prognosis and therapy resistance. Therefore, it represents a clinically relevant phenomenon that can be exploited for improvement of existing diagnostic and treatment procedures as well as for development of new targeted strategies. This book summarizes the current state of knowledge on hypoxia-regulated pathways and their biological consequences and describes promising approaches to clinical application of this knowledge. It is the first concise and complex guide to understanding principal basic and medical aspects of tumour hypoxia.

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