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Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy
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ISBN13: 9783662517987
Publisher: Springer
Published: Aug 23 2016
Pages: 845
Weight: 4.20
Height: 1.71 Width: 8.27 Depth: 10.98
Language: English
This book is divided into 3 parts. Part 1 summarizes the pro-angiogenic factors and anti-angiogenic molecules including their mechanism of action. Part 2 summarizes the preclinical data arising from the experimental evaluation of anti-angiogenic and pro-angiogenic compounds in cell culture and animal models. This will help to elucidate their mechanism of action in different biologic systems and cancer types. Based on this knowledge, clinicians will be able to incorporate these new drugs into the scenario of established therapies and finally improve curative approaches. Part 3 summarizes experimental and clinical studies of combined therapy with anti-angiogenic agents and highlights the challenges related to the appropriate strategies for selection of the patients, study design, and choice of proper end points for preclinical and clinical studies using these agents.
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