Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Tissue-Specific Estrogen Action: Novel Mechanisms, Novel Ligands, Novel Therapies

Tissue-Specific Estrogen Action: Novel Mechanisms, Novel Ligands, Novel Therapies

Wintermantel, Tim
Korach, Kenneth S.

Hardcover

Series: Ernst Schering Foundation Symposium Proceedings, Book 2006

Medical Reference

ISBN10: 3540495479
ISBN13: 9783540495475
Publisher: Springer
Published: Jun 12 2007
Pages: 181
Weight: 0.84
Height: 0.50 Width: 5.50 Depth: 8.50
Language: English
Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled The Second Decade and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand) binding to gene expression changes. In nuclear receptor molecular biology, estrogen receptor research has additional unique facets: since the discovery of ethinyl estradiol by Inhoffen and Hohlweg in the laboratories of Schering AG in the 1930s--and therefore several decades longer than nuclear receptor - searchitself--estrogenreceptorshavebeentargetsofwidelyused, orally administered drugs. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research.

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