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    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
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Taurine 4: Taurine and Excitable Tissues

Taurine 4: Taurine and Excitable Tissues

Della Corte, Laura
Sgaragli, Giampietro
Huxtable, Ryan J.

Paperback

Series: Advances in Experimental Medicine and Biology, Book 483

Medical ReferenceChemistry

ISBN10: 1475773420
ISBN13: 9781475773422
Publisher: Springer Nature
Published: Mar 12 2013
Pages: 652
Weight: 2.06
Height: 1.36 Width: 6.14 Depth: 9.21
Language: English
Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the setpoint andcorresponds to values between 0.3-3 M. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. membrane potential. ? pH gradient. Adapted from .

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