Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Structural Genomics and Human Health Implications

Structural Genomics and Human Health Implications

Kohler, Maria

Paperback

Medical ReferenceBiology

ISBN10: 1288255519
ISBN13: 9781288255511
Publisher: Biblioscholar
Published: Nov 9 2012
Pages: 46
Weight: 0.17
Height: 0.10 Width: 6.14 Depth: 9.21
Language: English

Robust biomedical research in the United States has led to many advances in modern medicine. Our current knowledge of genomics and proteomics has opened the door for many new technologies, which often merge several disciplines, such as molecular biology, biochemistry, and bioinformatics. One of those ever evolving technologies is protein X-ray crystallography which allows visualization of macromolecular structures at the atomic level and accurate determination of protein structures. An understanding of protein structure and function, brought about by structural genomics research, could have implications in civilian and military medicine with applications in new drug developments, enhanced vaccination efficacies and biological warfare agent neutralization. More specifically, knowing the structure of an enzyme, could lead to designing of a molecule that would bind to the active site of the enzyme and either activate or deactivate its action. This approach could be used in structural and functional analysis of proteins and may possibly play a role in diabetes, viral and bacterial infections, cancer and biotoxin action mechanisms. Third-generation synchrotrons, such as the one at the Argonne National Laboratory's Advance Photon Source, allow scientists to determine the three-dimensional protein structures at the highest resolution. Additionally, high-throughput structural genomics laboratories, such as Argonne's Midwest Center for Structural Genomics, make protein structures available for further studies to scientists around the world by rapidly solving and depositing them into protein databases.

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