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Statistical Monitoring of Clinical Trials: A Unified Approach
Hardcover
Series: Statistics for Biology and Health
ISBN13: 9780387300597
Publisher: Springer Nature
Published: Aug 3 2006
Pages: 268
Weight: 1.14
Height: 0.72 Width: 6.34 Depth: 9.28
Language: English
The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion (the B-value) - irrespective of the test statistic. Thus, this book offers statisticians an accessible, incremental approach to understanding Brownian motion as related to clinical trials. The main body of the chapters is accessible to anyone with knowledge of a standard mathematical statistics text. More mathematically advanced readers will find rigorous developments in appendices at the end of chapters. Reading the book will develop insight into not only monitoring, but power, survival analysis, safety, and other statistical issues germane to clinical trials.
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