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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique

Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique

Chaudhary Haresh
Patel B. N.
Patel D. M.

Paperback

Medical Reference

ISBN10: 384650405X
ISBN13: 9783846504055
Publisher: Lap Lambert Academic Pub
Published: Feb 13 2014
Pages: 124
Weight: 0.42
Height: 0.29 Width: 6.00 Depth: 9.00
Language: English
Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.

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