Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Superporous Hydrogel Tablets of Atenolol for Gastro-retention

Superporous Hydrogel Tablets of Atenolol for Gastro-retention

Patil Vibhute, Preeti
Hajare, Ashok

Paperback

Medical Reference

ISBN10: 6205633922
ISBN13: 9786205633922
Publisher: Lap Lambert Academic Pub
Published: Jan 18 2023
Pages: 104
Weight: 0.36
Height: 0.25 Width: 6.00 Depth: 9.00
Language: English
Gastro-retentive drug delivery system can retain the drug in the gastric region for several hours which enhances drug release and improves bioavailability. Atenolol, an antihypertensive drug has short half-life, limited bioavailability, highly unstable at basic pH and is extensively absorbed from the stomach. These features triggered the need of developing gastroretentive system. In the present study a superporous hydrogel was developed as a gastroretentive drug delivery system. Chitosan / poly (vinyl alcohol) interpenetrating polymer network (IPN) type superporous hydrogels were prepared using a gas foaming method employing glyoxal as the cross-linking agent. SPH tablets of atenolol were prepared by direct compression incorporating microcrystalline cellulose, magnesium stearate, talc and sodium bicarbonate, etc. and evaluated. The superporous hydrogels were highly sensitive to pH of swelling media and showed fast swelling and good porosity. SPH tablets of atenolol showed good precompressional and post-compressional properties. Formulation IV exhibited good swelling ratio and sustained release of drug over the period of 12 h through gastro-retention.

Also from

Patil Vibhute, Preeti

View All

Also in

Medical Reference

View All