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Stem Cell-Dependent Therapies: Mesenchymal Stem Cells in Chronic Inflammatory Disorders
Hardcover
Publisher Price: $360.00
ISBN13: 9783110298260
Publisher: De Gruyter
Published: Oct 17 2013
Pages: 426
Weight: 1.93
Height: 0.94 Width: 6.69 Depth: 9.61
Language: English
Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD).
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