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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Somatic Diversification of Immune Responses

Somatic Diversification of Immune Responses

Kelsoe, Garnett
Flajnik, Martin

Paperback

Series: Current Topics in Microbiology and Immmunology, Book 229

Medical ReferenceBiology

ISBN10: 3642719864
ISBN13: 9783642719868
Publisher: Springer Nature
Published: Dec 10 2011
Pages: 221
Weight: 0.75
Height: 0.51 Width: 6.14 Depth: 9.21
Language: English
Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo- ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re- markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec- tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.

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