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Simulation for Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective

Simulation for Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective

Paperback

Series: Drugs and the Pharmaceutical Sciences, Book 127

Medical Reference

ISBN10: 0367395606
ISBN13: 9780367395605
Publisher: Crc Pr Inc
Published: Sep 19 2019
Pages: 424
Weight: 1.10
Height: 0.80 Width: 6.00 Depth: 9.00
Language: English
Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to design clinical trials according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

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