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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Signposts to Chiral Drugs: Organic Synthesis in Action

Signposts to Chiral Drugs: Organic Synthesis in Action

Sunjic, Vitomir
Parnham, Michael

Hardcover

Medical ReferenceChemistry

ISBN10: 3034801246
ISBN13: 9783034801249
Publisher: Springer Nature
Published: May 12 2011
Pages: 232
Weight: 1.10
Height: 0.80 Width: 6.20 Depth: 9.20
Language: English

Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the reader with the fascinating achievements of synthetic and medicinal chemistry.

The book starts with an introduction treating the discovery and development of a new drug entity. Each of the 15 subsequent chapters presents one of the target structures and begins with a description of its biological profile as well as any known molecular mechanisms of action, underlining the importance of its structural and stereochemical features. This section is followed by detailed discussions of synthetic approaches to the chiral target structure, highlighting creative ideas, the scaling-up of laboratory methods and their replacement by efficient modern technologies for large-scale production. Nearly 60 synthetic reactions, most of them stereoselective, catalytic or biocatalytic, as well as chiral separating methodologies are included in the book.

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