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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Signaling Pathways for Translation: Insulin and Nutrients

Signaling Pathways for Translation: Insulin and Nutrients

Rhoads, Robert E.

Hardcover

Series: Progress in Molecular and Subcellular Biology, Book 26

BiologyChemistry

ISBN10: 3540417095
ISBN13: 9783540417095
Publisher: Springer Nature
Published: Jul 17 2001
Pages: 186
Weight: 0.91
Height: 0.65 Width: 6.20 Depth: 9.40
Language: English
The articles in the present volume are by major contributors to our under- standing of signaling pathways affecting protein synthesis. They focus pri- marily on two extracellular anabolic signals, although others are included as well. Insulin is one of the best-studied extracellular regulators of protein syn- thesis. Several of the known pathways for regulation of protein synthesis were elucidated using insulin-dependent systems. Regulation of protein synthesis by amino acids, by contrast, is an emerging field that has recently received a great deal of attention. The dual role of amino acids as substrates for protein syn- thesis and regulators of the overall process has only recently been recognized. Since amino acids serve as precursors for proteins, one might expect that with- holding an essential amino acid would inhibit the elongation phase. Surpris- ingly, research has shown that it is the initiation phase of protein synthesis that is restricted during amino acid starvation. Understanding the mechanisms by which the biosynthesis of proteins is reg- ulated is important for several reasons. Protein synthesis consumes a major portion of the cellular ATP that is generated. Therefore, small changes in protein synthesis can have great consequences for cellular energy metabolism. Translation is also a major site for control of gene expression, since messenger RNAs differ widely in translational efficiency, and changes to the protein syn- thesis machinery can differentially affect recruitment of individual mRNAs.

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