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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Scf and Apc E3 Ubiquitin Ligases in Tumorigenesis

Scf and Apc E3 Ubiquitin Ligases in Tumorigenesis

Inuzuka, Hiroyuki
Wei, Wenyi

Paperback

Series: Springerbriefs in Cancer Research

Medical ReferenceBiologyChemistry

ISBN10: 3319050257
ISBN13: 9783319050256
Publisher: Springer
Published: Apr 8 2014
Pages: 118
Weight: 0.55
Height: 0.30 Width: 5.90 Depth: 9.00
Language: English
This SpringerBrief explores thephysiological roles ofSkp1-Cullin1-F-box Complex(SCF) andAnaphase Promoting Complex (APC) in normal cells and in tumor formation. These tworelated, multi-subunit E3 ubiquitin ligase enzymes, APCandSCFare thought to be the major driving forces governing proper cell cycle progression.Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies thathave shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis.The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.

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