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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Ras Family Gtpases

Ras Family Gtpases

Der, Channing

Hardcover

Series: Proteins and Cell Regulation, Book 4

Medical ReferenceAnatomy & PhysiologyBiology

ISBN10: 1402043287
ISBN13: 9781402043284
Publisher: Springer Nature
Published: Sep 13 2006
Pages: 397
Weight: 1.88
Height: 0.85 Width: 6.56 Depth: 9.46
Language: English

Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons.

First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates.

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