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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Role of TREK background potassium channels in nociception

Role of TREK background potassium channels in nociception

Akki, Rachid
Noël, Jacques
Errami, Mohammed

Paperback

Biology

ISBN10: 6630199987
ISBN13: 9786630199987
Publisher: Our Knowledge Publishing
Published: Jun 11 2026
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: English
Potassium channels with two pore domains (K2p) generate background K+ currents, which play a major role in membrane depolarization and cellular excitability. They are implicated in anesthesia, neuroprotection, depression, and pain. The K2p channel subfamily-TREK-1, TREK-2, and TRAAK-is modulated by pH, lipids (including polyunsaturated fatty acids), membrane stretching, and temperature. TREK-1 and TREK-2 are inactivated by phosphorylation of the G protein-coupled receptor (GPCR) via PKA and PKC. The analgesic effects of morphine are mediated by various signaling pathways downstream of μ-opioid receptors, and TREK channels contribute to morphine-induced analgesia in mice. Here, we investigated the response of the dorsal root ganglion (DRG) in wild-type and triple-KO TREK-1-/- -TREK-2-/--TRAAK-/- mice to the application of morphine and capsaicin using calcium imaging. We also characterized an anti-TREK-2 antibody to study TREK-2 expression in DRG neurons.

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