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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Rise and Fall of Epithelial Phenotype: Concepts of Epithelial-Mesenchymal Transition

Rise and Fall of Epithelial Phenotype: Concepts of Epithelial-Mesenchymal Transition

Savagner, Pierre

Hardcover

Series: Molecular Biology Intelligence Unit

Medical ReferenceBiology

ISBN10: 0306482398
ISBN13: 9780306482397
Publisher: Springer Nature
Published: Jul 13 2005
Pages: 248
Weight: 1.40
Height: 0.90 Width: 6.30 Depth: 9.20
Language: English

Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT).

The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.

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