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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Resistance to Photodynamic Therapy in Cancer

Resistance to Photodynamic Therapy in Cancer

Rapozzi, Valentina
Jori, Giulio

Hardcover

Series: Resistance to Targeted Anti-Cancer Therapeutics, Book 5

Medical ReferenceBiology

ISBN10: 3319127292
ISBN13: 9783319127293
Publisher: Springer Nature
Published: Apr 7 2015
Pages: 248
Weight: 1.22
Height: 0.63 Width: 6.14 Depth: 9.21
Language: English
This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.

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