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Rational Drug Design: Methods and Protocols
Hardcover
Series: Methods in Molecular Biology, Book 928
ISBN13: 9781627030076
Publisher: Springer Nature
Published: Sep 6 2012
Pages: 230
Weight: 1.35
Height: 0.80 Width: 7.00 Depth: 10.10
Language: English
1. On Setting up and Assessing Docking Simulations for Virtual Screening
Jacek Biesiada, Aleksey Porollo, Jaroslaw Meller
2. Virtual Ligand Screening Combined with NMR to Identify Dvl PDZ Domain Inhibitors Targeting the Wnt Signaling
Jufang Shan and Jie J. Zheng
3. Rational Design of Rho GTPase Targeting Inhibitors
Xun Shang and Yi Zheng
4. Rational Design of Peptide Ligands Against a Glycolipid by NMR StudiesWenyong Tong, Tara Sprules, Kalle Gehring, H. Uri Saragovi
5. A Combinatorial Strategy for the Acquisition of Potent and Specific Protein Tyrosine Phosphatase Inhibitors
Sheng Zhang, Lan Chen, David S. Lawrence and Zhong-Yin Zhang
6. Identification of Allosteric Inhibitors of p21-Activated Kinase
Julien Viaud and Jeffrey R. Peterson
7. Using a Modified Yeast Two-hybrid System to Screen for Chemical GEF InhibitorsAnne Blangy and Philippe Fort .
8. Random Mutagenesis of Peptide Aptamers As An Optimization Strategy for Inhibitor Screening
Nathalie Bouquier, Sylvie Fromont, Anne Debant and Susanne Schmidt
9. A Screening Strategy for Trapping the Inactive Conformer of a Dimeric Enzyme with a Small Molecule Inhibitor
Tina Shahian and Charles S. Craik
10. Use of a Fluorescent ATP Analog to Probe the Allosteric Conformational Change in the Active Site of the Protein Kinase PDK1
Valerie Hindie, Laura A. Lopez-Garcia, and Ricardo M. Biondi
11. Affinity Purification of Protein Kinases that Adopt a Specific Inactive ConformationPratistha Ranjitkar and Dustin J. Maly 12. Determination of the Kinetics and Thermodynamics of Ligand Binding to a Specific Inactive Conformation in Protein KinasesSanjay B. Hari, Pratistha Ranjitkar and Dustin J. Maly
13. Purification and Specific Assays for Measuring APE-1 Endonuclease Activity
Adrian Esqueda, Mohammed Z Mohammed, Srinivasan Madhusudan, and Nouri Neamati
14. An in vitro Screening to Identify Drug Resistant Mutations for Target-directed Chemotherapeutic Agents
Mohammad Azam
15. Utilizing AntagomiR (anti-sense microRNA) to Knock Down microRNA in Murine Bone Marrow Cells
Chinavenmeni S. Velu and H. Leighton Grimes
16. Synthesis, Conjugation, and Labeling of Multifunctional pRNA Nanoparticles for Specific Delivery of siRNA, Drugs and Other Therapeutics to Target Cells
Mathieu Cinier, Yi Shu, Daniel Binzel, and Peixuan Guo
17. Mouse Models for Tumor Metastasis
Shengyu Yang, J. Jillian Zhang, and Xin-Yun Huang
1. On Setting up and Assessing Docking simulations for Virtual Screening
Jacek Biesiada, Aleksey Porollo, Jaroslaw Meller
2. Virtual Ligand Screening Combined with NMR to Identify Dvl PDZ Domain Inhibitors Targeting the Wnt Signaling
Jufang Shan and Jie J. Zheng
3. Rational Design of Rho GTPase Targeting Inhibitors
Xun Shang and Yi Zheng
4. Rational Design of Peptide Ligands Against a Glycolipid by NMR StudiesWenyong Tong, Tara Sprules, Kalle Gehring, H. Uri Saragovi
5. A Combinatorial Strategy for the Acquisition of Potent and Specific Protein Tyrosine Phosphatase Inhibitors
Sheng Zhang, Lan Chen, David S. Lawrence and Zhong-Yin Zhang
6. Identification of Allosteric Inhibitors of p21-Activated Kinase
Julien Viaud and Jeffrey R. Peterson
7. Using a Modified Yeast Two-hybrid System to Screen for Chemical GEF InhibitorsAnne Blangy and Philippe Fort .
8. Random Mutagenesis of Peptide Aptamers As An Optimization Strategy for Inhibitor Screening
Nathalie Bouquier, Sylvie Fromont, Anne Debant and Susanne Schmidt
9. A Screening Strategy for Trapping the Inactive Conformer of a Dimeric Enzyme with a Small Molecule Inhibitor
Tina Shahian and Charles S. Craik
10. Use of a Fluorescent ATP Analog t
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