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Radiopharmaceuticals: Introduction to Drug Evaluation and Dose Estimation
Hardcover
Medical ReferenceChemistryPhysics
ISBN13: 9781439810675
Publisher: CRC Press
Published: Dec 14 2010
Pages: 326
Weight: 1.40
Height: 0.75 Width: 6.14 Depth: 9.21
Language: English
This comprehensive overview details the process of radiopharmaceutical development, from cellular studies to animal experiments to the design and implementation of clinical trials. It compares various radiopharmaceuticals and provides guidance on dose estimation and agent selection, covering standard medical internal radiation dose (MIRD), absorbed dose method for imaging agents, in vivo methods for obtaining activity data, errors of activity estimation techniques, and phantom-based and patient-based dose estimates. Backed by examples from clinical trials, it discusses two and three dimensional estimation processes, including the use of modern hybrid scanners such as SPECT /CT and PET/CT.
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