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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Quorum sensing and biofilm formation in Staphylococcus aureus

Quorum sensing and biofilm formation in Staphylococcus aureus

Audretsch, Christof

Paperback

Biology

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ISBN10: 3838138414
ISBN13: 9783838138411
Publisher: Sudwestdeutscher Verlag Fur Ho
Published: Apr 15 2014
Pages: 128
Weight: 0.44
Height: 0.30 Width: 6.00 Depth: 9.00
Language: English
Staphylococcus aureus (SA) is an important pathogen causing many diseases, especially nosocomial infections. It forms biofilms to protect itself from the host and antibiotics. Biofilm and planctonic life style is regulated by a complex Quorum-Sensing (QS) system with agr as a central regulator. To study biofilm formation and QS in SA a Boolean network was build and thoroughly validated using data from microarrays, northern blots and biofilm adherence assays. Network analysis revealed sae and agr as central regulators and showed two stable states, biofilm forming versus planctonic, with clearly different subnetworks turned on. This network represents a powerful tool to study QS and biofilm formation in SA. Moreover it was found that the sae-locus is also a central repressor of biofilm production and nucleases might play an important role in connecting sae to the biofilm forming ability. Biofilm experiments revealed differences in the composition of mutant biofilms leading us in perspective towards a new understanding of biofilms themselves including knowledge how to better regulate, fight and use them.

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