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Proteomics for Drug Discovery: Methods and Protocols
Hardcover
Series: Methods in Molecular Biology, Book 1647
ISBN13: 9781493972005
Publisher: Humana Pr
Published: Aug 15 2017
Pages: 302
Weight: 1.69
Height: 0.75 Width: 7.00 Depth: 10.00
Language: English
1. A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates
Jason R. Thomas, Scott M. Brittain, Jennifer Lipps, Luis Llamas, Rishi K. Jain, and Markus Schirle
2. Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins
Yi Chen, Kate J. Fisher, Mark Lloyd, Elizabeth R. Wood, Domenico Coppola, Erin Siegel, David Shibata, Yian A. Chen, and John M. Koomen
3. Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics
Mathias Kalxdorf, Hans Christian Eberl, and Marcus Bantscheff
4. High Resolution Parallel Re
action Monitoring with Electron Transfer Dissociation for Middle-Down Proteomics: An Application to Study the Quantitative Changes Induced by Histone Modifying Enzyme Inhibitors and ActivatorsMichael J. Sweredoski, Annie Moradian, and Sonja Hess
5. Preparation and Immunoaffinity Depletion of Fresh Frozen Tissue Homogenates for Mass Spectrometry-Based Proteomics in the Context of Drug Target/Biomarker Discovery
DaRue A. Prieto, King C. Chan,2Donald J. Johann, Jr., Xiaoying Ye, Gordon Whitely, and Josip Blonder
6. Target Identification Using Cell Permeable and Cleavable Chloroalkane Derivatized Small Molecules
Jacqui L. Mendez-Johnson, Danette L. Daniels, Marjeta Urh, and Rachel Friedman Ohana
&
nbsp;7. Microfluidics-Mass Spectrometry of Protein-Carbohydrate Interactions: Applications to Development of Therapeutics and Biomarker Discovery
Alina D. Zamfir
8. Studying Protein-Protein Interactions by Biotin AP-Tagged Pulldown and LTQ-Orbitrap Mass Spectrometry
Zhongqiu Xie, Yuemeng Jia, and Hui Li
9. Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation
Avital Eisenberg-Lerner, Ifat Regev, and Yifat Merbl
10. Reverse Phase Protein Arrays and Drug Discovery
Kenneth G. Macleod, Bryan Serrels, and Neil O. Carragher
&
lt;11. Probing Protein Kinase-ATP Interactions Using a Fluorescent ATP AnalogLeslie E.W. LaConte, Sarika Srivastava, and Konark Mukherjee
12. Preparation of Disease-Related Protein Assemblies for Single Particle Electron Microscopy
A. Cameron Varano, Naoe Harafuji, William Dearnaley, Lisa Guay-Woodford, and Deborah F. Kelly
13. Identification of Lipid-Binding Modulators Using the Protein-Lipid Overlay Assay
Tuo-Xian Tang, Wen Xiong, Carla V. Finkielstein, and Daniel G.S. Capelluto
14. Resazurin Live Cell Assay: Setup and Fine-Tuning for Reliable Cytotoxicity
José Á. Rodríguez-Corrales and Jatinder S. J
osan
15. Exploring Protein-Protein Interactions as Drug Targets for Anti-Cancer Therapy with In Silico Workflows
Alexander Goncearenco, Minghui Li, Franco Simonetti, Benjamin A. Shoemaker, and Anna R. Panchenko
16. Method to Identify Silent Codon Mutations that May Alter Peptide Elongation Kinetics and Co-Translational Protein Folding
Ronald Worthington, Elijah Ball, Brentsen Wolf, and Gregory Takacs
17. In Silico Design of Anticancer Peptides
Shailesh Kumar and Hui Li
18. Docking and Virtual Screening in Drug Discovery
Maria Kontoyianni
19. Bioinfo
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