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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Physical Methods to Characterize Pharmaceutical Proteins

Physical Methods to Characterize Pharmaceutical Proteins

Herron, James N.
Jiskoot, Wim
Crommelin, Daan J. a.

Hardcover

Series: Pharmaceutical Biotechnology, Book 7

Medical ReferenceBiologyZoology

ISBN10: 0306450267
ISBN13: 9780306450266
Publisher: Springer Nature
Published: Sep 30 1995
Pages: 362
Weight: 1.57
Height: 0.88 Width: 6.14 Depth: 9.21
Language: English
Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from traditional low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from both industrial and aca- demic environments, forcing pharmaceutical scientists to explore a domain previ- ously examined only by peptide and protein chemists. Biopharmaceutical aspects of proteins, e.g., low oral bioavailability, have been extensively investigated. Although all possible conventional routes of ad- ministration have been examined for proteins, no real, generally applicable alter- native to parenteral administration in order to achieve systemic effects has yet been discovered. Several of these biopharmaceutical options have been discussed in Volume 4 of this series, Biological Barriers to Protein Delivery. Proteins are composed of many amino acids, several of which are notorious for their chemical instability. Rational design of formulations that optimize the native structure and/or bioactivity of a protein is therefore of great importance when long shelf life is required, as it is for pharmaceutical products. This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs.

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