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Protein Quality Control in Neurodegenerative Diseases

Protein Quality Control in Neurodegenerative Diseases

Hardcover

Series: Research and Perspectives in Alzheimer's Disease, Book 0

Medical ReferenceBiology

ISBN10: 3642279279
ISBN13: 9783642279270
Publisher: Springer
Published: Dec 12 2012
Pages: 136
Weight: 0.76
Height: 0.54 Width: 6.28 Depth: 9.46
Language: English
The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

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Morimoto, Richard I.

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Biology