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Rumo à utilização de compostos naturais como agentes antigliomatosos
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ISBN10: 6630435346
ISBN13: 9786630435344
Publisher: Edicoes Nosso Conhecimento
Published: Aug 13 2026
Pages: 156
Weight: 0.48
Height: 0.36 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786630435344
Publisher: Edicoes Nosso Conhecimento
Published: Aug 13 2026
Pages: 156
Weight: 0.48
Height: 0.36 Width: 6.00 Depth: 9.00
Language: Portuguese
A quimioprevenção e o tratamento do cancro através de compostos naturais têm-se revelado uma abordagem promissora e pragmática para reduzir o impacto do cancro. Os compostos naturais representam mais de 60% dos medicamentos quimioterapêuticos anticancerÃgenos atualmente utilizados. A identificação e caracterização de novos compostos naturais anti-glioma provenientes de ervas medicinais da Medicina Tradicional Chinesa constituiu o principal objetivo deste livro. Ao contrário dos fármacos que são igualmente tóxicos tanto para as células cancerosas como para as células normais, identificámos compostos naturais que são bastante tóxicos para as células cancerosas, mas menos tóxicos para as células normais. A indução da apoptose e a paragem do ciclo celular foram os principais mecanismos associados aos efeitos anticancerÃgenos destes compostos bioativos. Verificou-se que a indução do stress oxidativo até um limiar tóxico - o que é facilmente alcançável nas células cancerosas em comparação com as células normais - constitui a principal razão da citotoxicidade seletiva destes compostos.
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