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Dickeya dadantii: compreendendo o papel biológico dos OPG
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ISBN10: 6209598137
ISBN13: 9786209598135
Publisher: Edicoes Nosso Conhecimento
Published: Feb 2 2026
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209598135
Publisher: Edicoes Nosso Conhecimento
Published: Feb 2 2026
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Portuguese
Os glucanos periplasmáticos osmorregulados (OPG) são oligómeros de glicose. D. dadantii, um fitopatógeno com amplo espectro de hospedeiros, causa a doença da podridão mole. Nesta bactéria, um mutante desprovido de OPG apresenta um fenótipo pleiotrópico: perda total da virulência, diminuição da motilidade, indução geral de uma resposta ao stress, sugerindo uma grave deficiência na perceção do ambiente. Esta ideia é reforçada pela ligação entre os sistemas de dois componentes, sistemas-chave na perceção do ambiente, e os OPG. Uma abordagem exploratória sobre o papel dos OPG na virulência permitiu demonstrar que, num mutante sem OPG, a inativação do pecS, principal repressor da virulência, permite restaurar a virulência na folha de endÃvia. A conservação de vários fenótipos associados ao defeito de sÃntese de OPG indica que as duas mutações não afetam uma única via de regulação. Por fim, a identificação do gene que codifica a enzima responsável pela succinilação dos OPG permitiu completar o conjunto de genes envolvidos na biossÃntese dos OPG.
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