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Bactérias resistentes aos antibióticos nas águas residuais
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ISBN10: 6208674239
ISBN13: 9786208674236
Publisher: Edicoes Nosso Conhecimento
Published: Feb 24 2025
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208674236
Publisher: Edicoes Nosso Conhecimento
Published: Feb 24 2025
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
Os carbapenemes (antibióticos beta-lactâmicos) desempenham um papel central contra as infecções bacterianas e servem como antibióticos de reserva. As Enterobacteriaceae, que podem desenvolver resistência aos carbapenemes através de carbapenemases, estão presentes no trato digestivo humano e animal e podem também entrar nas águas residuais. Por conseguinte, a epidemiologia baseada nas águas residuais oferece uma boa oportunidade para o rastreio da resistência aos antibióticos. O objetivo do trabalho foi detetar Enterobacteriaceae resistentes aos carbapenemes e os seus mecanismos de resistência nas águas residuais de Graz. As águas residuais não tratadas e tratadas foram analisadas em placas MacConkey e Chromagar. As colónias foram identificadas utilizando MALDI-TOF-MS, os antibiogramas foram preparados de acordo com os critérios EUCAST e as carbapenemases foram sequenciadas. 31 isolados eram portadores do gene raro KPC-2, não só em Klebsiella pneumoniae mas também em Enterobacter spp. As estirpes produtoras de KPC-2 mostraram maioritariamente resistência aos carbapenemes e à cefepima. Além disso, foi detectado pela primeira vez na Áustria um isolado GES-5.
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