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Atividade anticancerÃgena do Clerodendrum serratum em ratos albinos
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ISBN10: 6209989365
ISBN13: 9786209989360
Publisher: Edicoes Nosso Conhecimento
Published: May 7 2026
Pages: 140
Weight: 0.43
Height: 0.33 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209989360
Publisher: Edicoes Nosso Conhecimento
Published: May 7 2026
Pages: 140
Weight: 0.43
Height: 0.33 Width: 6.00 Depth: 9.00
Language: Portuguese
A pele, uma das principais interfaces do corpo com o ambiente, está exposta, acidentalmente ou por motivos profissionais, a uma série de mutagénicos e carcinogéneos quÃmicos. O cancro da pele representa 30% de todos os cancros diagnosticados no mundo. A avaliação da atividade anticancerÃgena do extrato de folhas de Clerodendrum serratum na carcinogênese cutânea induzida por DMBA em ratos albinos suÃços revelou que houve diminuição no peso corporal e dos órgãos, alterações nos parâmetros bioquÃmicos, nas atividades das desidrogenases e fosfatases e nos parâmetros de estresse oxidativo do fÃgado, rins e testÃculos dos ratos. Observou-se uma melhoria nos parâmetros acima mencionados após o tratamento com o extrato metanólico de folhas de Clerodendrum serratum, indicando o seu potencial anticancerÃgeno. As conclusões tiradas do estudo revelaram que o extrato metanólico de folhas de Clerodendrum serratum restaurou os parâmetros bioquÃmicos, a atividade das desidrogenases e fosfatases e os parâmetros de stress oxidativo do fÃgado, rins e testÃculos dos ratos. A presença de componentes quÃmicos importantes, tais como fenólicos, esteróides, diterpenos e triterpenos, flavonóides e óleos voláteis, atribuiu-lhe potencial quimiopreventivo como agente antioxidante e antiproliferativo........
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