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Análise molecular do vÃrus da hepatite C na população marroquina
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ISBN10: 6209525679
ISBN13: 9786209525674
Publisher: Edicoes Nosso Conhecimento
Published: Jan 28 2026
Pages: 80
Weight: 0.26
Height: 0.19 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209525674
Publisher: Edicoes Nosso Conhecimento
Published: Jan 28 2026
Pages: 80
Weight: 0.26
Height: 0.19 Width: 6.00 Depth: 9.00
Language: Portuguese
A evolução do vÃrus da hepatite C (VHC) é um processo altamente dinâmico. Há pouca informação sobre a epidemiologia molecular dos isolados do VHC em Marrocos, uma área conhecida por uma prevalência intermédia da infeção pelo VHC. O objetivo deste estudo foi determinar a distribuição dos subtipos das estirpes do VHC em doentes com infeção crónica pelo VHC em Marrocos e estimar a prevalência de substituições de aminoácidos na região central do VHC em doentes marroquinos sem tratamento prévio. Neste estudo, incluÃmos 185 doentes anti-VHC positivos. A identificação do subtipo do VHC foi realizada, respetivamente, através do sequenciamento das regiões 5'UTR, núcleo e NS5B. A história demográfica do VHC foi inferida utilizando uma análise bayesiana de cadeia de Markov Monte Carlo. A análise filogenética baseada na região NS5B revelou que o subtipo 1b (75,2%) era o mais comum, seguido pelo subtipo 2i (19,1%). O subtipo 1b do HCV teve uma prevalência ainda maior no carcinoma hepatocelular. Utilizando uma abordagem bayesiana, a data média de aparecimento do ancestral comum mais recente foi estimada em 1910 para o HCV-1b e 1854 para o HCV-2i. Com base na região core, foram detetadas mutações em R70Q ou L91M em mais de um quarto dos pacientes infectados com HCV-1b.
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