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Ação do Verapamil
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ISBN10: 6208469368
ISBN13: 9786208469368
Publisher: Edicoes Nosso Conhecimento
Published: Aug 30 2025
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208469368
Publisher: Edicoes Nosso Conhecimento
Published: Aug 30 2025
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: Portuguese
A fibrose hepática progride para cirrose na hepatite alcoólica e produz disfunção hepatocelular, que é um fator de risco para o carcinoma hepatocelular. Este estudo investiga a toxicidade potencial do CCl4 iniciada pelo etanol como agentes hepatotóxicos na estrutura celular do fÃgado, glicogénio, conteúdo de ADN e certas enzimas, e também avalia o efeito de um certo antagonista de iões de cálcio, como o verapamil, na lesão celular hepática induzida por tetracloreto de carbono e álcool etÃlico em ratos. A microscopia óptica revelou que os ratos que receberam etanol e CCl4 combinados apresentaram fibrose e necrose das células hepáticas, fragmentação nuclear e resposta inflamatória. Também foram detectados distúrbios do glicogénio e danos no ADN. Por outro lado, os animais que receberam verapamil apresentaram redução da degeneração e necrose dos hepatócitos, e foi detectado um atraso na formação da fibrose hepática. Houve uma melhora acentuada na arquitetura dos hepatócitos, no glicogénio e no conteúdo de ADN. Estudos de microscopia eletrónica e bioquÃmicos parecem confirmar esses achados.
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