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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Phylogenetic Analysis of Viral Quasispecies

Phylogenetic Analysis of Viral Quasispecies

Buendia, Patricia

Paperback

Medical ReferenceBiology

ISBN10: 383643458X
ISBN13: 9783836434584
Publisher: Vdm Verlag
Published: Jan 7 2008
Pages: 212
Weight: 0.76
Height: 0.45 Width: 6.69 Depth: 9.61
Language: English
A new approach in the analysis of viral evolution is presented in this book, an approach that merges Phylogenetic analysis and Bioinformatic techniques. Patterns of viral evolution are inferred from serially-sampled sequence data, i.e., sequence data obtained from strains isolated at consecutive time points from a single patient or host. Traditional phylogenetic methods assume a tree-like evolutionary model, while many RNA viruses have the capacity to exchange genetic material with one another using a process called re-combination. A genealogy involving recombination is best described by a net-work structure. A more general approach was implemented in a new compu-tational tool, Sliding MinPD, one that is mindful of the sampling times of the input sequences and that reconstructs the viral evolutionary relationships in the form of a network structure with implicit representations of recombi-nation events. The underlying network organization reveals unique patterns of viral evolution and could help explain the emergence of disease-associated mutants and drug-resistant strains, with implications for patient prognosis and treatment strategies.

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