Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Phosphodiesterases: CNS Functions and Diseases

Phosphodiesterases: CNS Functions and Diseases

Zhang, Han-Ting
Xu, Ying
O'Donnell, James M.

Hardcover

Series: Advances in Neurobiology, Book 17

Medical ReferenceCognition

ISBN10: 3319588095
ISBN13: 9783319588094
Publisher: Springer
Published: Oct 6 2017
Pages: 471
Weight: 1.90
Height: 1.06 Width: 6.14 Depth: 9.21
Language: English
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

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