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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Pharmacological preconditioning and ischaemic postconditioning in experimental jejunal ischaemia in horses

Pharmacological preconditioning and ischaemic postconditioning in experimental jejunal ischaemia in horses

Verhaar, Nicole

Paperback

Medical Reference

ISBN10: 3736974337
ISBN13: 9783736974333
Publisher: Cuvillier
Published: Jun 1 2021
Pages: 146
Weight: 0.40
Height: 0.31 Width: 5.83 Depth: 8.27
Language: English
Strangulating obstruction of the small intestine in the horse is associated with a high mortality rate. Although many intestinal lesions can be treated surgically, more effective strategies are needed to decrease the occurrence of complications related to the intestinal segments that are not amenable to intestinal resection. The aim of this PhD was to determine the feasibility and effect of two novel treatment modalities in equine small intestinal ischaemia. Therefore, ischaemic postconditioning and pharmacological preconditioning with lidocaine and xylazine were investigated in two experimental in vivo studies. By evaluating different variables for intestinal ischaemia reperfusion injury by use of histomorphology, immunohistochemistry and biochemical analysis, the results of this study demonstrate the applicability of these treatments in experimental small intestinal ischaemia in horses.

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