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Pegylated Protein Drugs: Basic Science and Clinical Applications
Hardcover
Series: Milestones in Drug Therapy
ISBN13: 9783764386788
Publisher: Springer Nature
Published: Sep 18 2009
Pages: 290
Weight: 1.30
Height: 0.90 Width: 6.30 Depth: 9.30
Language: English
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
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