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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Pathological response of breast carcinomas after chemotherapy

Pathological response of breast carcinomas after chemotherapy

Ben Makhlouf, Wiem
Boudaouara, Ons

Paperback

Medical Reference

ISBN10: 6208954800
ISBN13: 9786208954802
Publisher: Our Knowledge Publishing
Published: Jun 17 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: English
Pathological complete response (pCR) in Her-2 positive breast cancer is the ultimate goal of every oncologist, as it is associated with a better prognosis in these patients. Thus, several authors have attempted to explore the factors that may influence the quality of pathological response to neoadjuvant chemotherapy (NAC), in an attempt to predict the pathological response expected by the tumor. In this work, we investigated the factors potentially predictive of a pCR and the prognostic impact of the latter, through a retrospective study of 34 patients with Her-2 positive breast carcinoma treated by surgery after NAC over a 10-year period between 2013 and 2023. A pCR was obtained in 7 patients (20.6%). Tumors with RH-negative status/overexpressed Her-2 molecular subtype responded better to NAC than their RH-positive or Luminal B molecular subtype counterparts. Therapeutically, the addition of neoadjuvant Trastuzumab was significantly predictive of pCR. At the same time, the achievement of pCR was associated with a better prognosis.

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