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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Pancreatic Islet Isolation: From the Mouse to the Clinic

Pancreatic Islet Isolation: From the Mouse to the Clinic

Ramírez-Domínguez, Miriam

Hardcover

Series: Advances in Experimental Medicine and Biology, Book 938

Medical ReferenceTechnology & EngineeringBiology

ISBN10: 3319398229
ISBN13: 9783319398228
Publisher: Springer Nature
Published: Sep 16 2016
Pages: 123
Weight: 1.01
Height: 0.38 Width: 7.00 Depth: 10.00
Language: English
Pancreatic islets make up the endocrine pancreas and they contain the only source of insulin in the body, beta cells. Hence, access to high quality preparations of pancreatic islets is fundamental for in vitro studies and to test pre-clinical applications in animal models in vivo. Access to healthy human islets is also crucial to improve transplantation procedures for diabetes. Given the susceptibility of pancreatic islets to the enzymatic digestion and mechanical stress required to obtain them, the isolation of islets is often considered as the delicate work of a craftsman. This book, which is aimed at beginners and experts alike, is a survey of the current state-of-the-art in this field and it centres on the challenges, pitfalls and peculiarities of pancreatic islet isolation in the different species used in pre-clinical and clinical applications. It explores the similarities and differences between human islets and those from other relevantspecies (rodents, pigs and non-human primates), and how these influence islet isolation. The ultimate goal of this book is to improve the outcome of islet isolation and transplantation in pre-clinical and clinical applications.

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