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Overlap syndromes

Overlap syndromes

Paperback

Medical Reference

ISBN10: 6209130917
ISBN13: 9786209130915
Publisher: Our Knowledge Publishing
Published: Oct 20 2025
Pages: 124
Weight: 0.39
Height: 0.29 Width: 6.00 Depth: 9.00
Language: English
The overlap syndrome (OS) between autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and/or primary sclerosing cholangitis (PSC) is a rare and complex syndrome. It represents a real diagnostic and therapeutic challenge.The objectives of this study were to analyze the epidemiological, clinical-biological, and histological aspects of AIH and SC and to define their evolutionary and prognostic characteristics.Methods: We conducted a retrospective comparative study over a 15-year period, including patients treated for AIH (G1) or SC (G2). We collected and compared epidemiological, clinical, paraclinical, therapeutic, and evolutionary data.Results: According to our study, the diagnosis of pure AIH or in the context of SC is made at a late stage, limiting therapeutic options. However, immunosuppressive treatment resulted in a complete response in the majority of cases.

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Hassine, Hajer

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Medical Reference