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Osteoimmunology: Interactions of the Immune and Skeletal Systems II

Osteoimmunology: Interactions of the Immune and Skeletal Systems II

Paperback

Series: Advances in Experimental Medicine and Biology, Book 658

Medical ReferenceBiology

ISBN10: 146142495X
ISBN13: 9781461424956
Publisher: Springer Nature
Published: Feb 25 2012
Pages: 122
Weight: 0.45
Height: 0.30 Width: 6.14 Depth: 9.21
Language: English

It has only recently been appreciated that the immune and skeletal systems have major interactions. It is now well documented that osteoclasts, which are important cellular mediators of skeletal homeostasis, are derived from hematopoietic precursors that also give rise to immune cells. In addition, numerous cytokines that were first shown to regulate immune cell function have also been demonstrated to regulate bone cells and influence skeletal health. Conversely, products of bone cells appear critical for the engraftment of marrow in bone, the normal development of the hematopoietic and immune systems and provide niche for long-term memory B and T cells.

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