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Non Viral Gene Therapy: Gene Design and Delivery Vol 1
Hardcover
ISBN13: 9781787153950
Publisher: Kruger Brentt Publisher Uk. Ltd.
Published: Jan 1 2025
Pages: 322
Weight: 2.28
Height: 0.75 Width: 8.50 Depth: 11.00
Language: English
Principles of Non-Viral Gene Therapy: Provide a comprehensive introduction to the principles of non-viral gene therapy, including the advantages and limitations compared to viral-based methods. Discuss the basic concepts of gene therapy, gene transfer, and the fundamental goals of therapeutic gene delivery.
Gene Design Strategies: Explore various strategies for designing therapeutic genes, including gene editing techniques (e.g., CRISPR/Cas9), synthetic gene constructs, and expression vectors. Discuss the considerations for optimizing gene design for therapeutic efficacy, stability, and expression.
Non-Viral Delivery Systems: Examine the different non-viral delivery systems used for gene transfer, including physical methods (e.g., electroporation, microinjection), chemical methods (e.g., liposomes, nanoparticles), and biological methods (e.g., cell-penetrating peptides). Discuss the mechanisms, advantages, and challenges associated with each delivery system.
Applications and Therapeutic Outcomes: Discuss the applications of non-viral gene therapy in various therapeutic areas, such as cancer treatment, genetic disorders, and regenerative medicine. Provide case studies and examples of successful non-viral gene therapy applications and their outcomes in clinical and preclinical settings.
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