Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Necrotizing Enterocolitis: Insights Into the Pathogenesis of This Challenging Disease

Necrotizing Enterocolitis: Insights Into the Pathogenesis of This Challenging Disease

Caplan, Michael S.

Paperback

Series: Colloquium Integrated Systems Physiology: From Molecule to Function to Disease

Medical Reference

ISBN10: 1615045902
ISBN13: 9781615045907
Publisher: Morgan & Claypool
Published: Dec 1 2013
Pages: 94
Weight: 0.38
Height: 0.19 Width: 7.50 Depth: 9.25
Language: English
Necrotizing enterocolitis is an acute inflammatory necrosis of bowel that primarily afflicts premature infants in the neonatal intensive care unit setting. Although patients who develop this disease have high morbidity and mortality rates, the pathogenesis is poorly understood, and therefore there are no specific preventive or treatment strategies that have been clearly effective. Recent studies have suggested that the pathophysiology of necrotizing enterocolitis includes alterations in the inflammatory response leading to dysregulated pro-inflammatory signaling in premature infants, as well as abnormal intestinal bacterial colonization patterns that can activate these inflammatory pathways, and these factors are discussed in depth in the following chapters. While human milk feedings are currently the standard of care for the prevention of this challenging condition, new approaches will be described based on sound evidence that might have a significant impact for premature infants throughout the world.

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