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Natural Products from Actinomycetes: Diversity, Ecology and Drug Discovery
Hardcover
ISBN13: 9789811661310
Publisher: Springer Nature
Published: Apr 16 2022
Pages: 508
Weight: 1.99
Height: 1.13 Width: 6.14 Depth: 9.21
Language: English
Section 1: Diversity, Chemical biology and Ecology of Actinomycetes; and the Discovery of Natural Products
Chapter 1: An overview on Natural products from Actinomycetes: their discovery and biosynthesis.
Chapter 2: Isolation, identification (cultural and molecular techniques), and systematics of Actinomycetes from various sources (marine, soil, extremophilic environment).Chapter 3: Studies on diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Actinomycetes strains.
Chapter 4: Chemical elicitors and signaling molecules and their role in elicitation of secondary metabolism in Actinomycetes.
Chapter 5: Regulation of antibiotic biosynthesis genes in Actinomycetes at molecular level.
Chapter 6: Screening strategies for inhibitors against cancer cells from natural Products repository of Actinomycetes.
Chapter 7: Rare and endophytic Actinomycetes in the biosynthesis of bioactive metabolites.
Chapter 8: Advances in bioactivity guided isolation of natural products from Actinomycetes.Chapter 9: Natural product discovery from non-Streptomyces Actinomycetes.
Chapter 10: Use of high-efficiency CRISPR/Cas9-mediated genome editing to study biology of Actinomycetes.
Section 2: Genomic approaches and synthetic biology tools in Actinomycetes drug discovery and industrial compounds
Chapter 11: An overview of biomedical, biotechnological and industrial applications of Actinomycetes
Chapter 12: Genomics and proteomics approach in natural product discovery in Actinomycetes.Chapter 13: Structural dereplication and strain dereplication strategies and metabolomics in natural product research.
Chapter 14: Genome mining of rare Actinomycetes and cryptic pathways for secondary metabolites.
Chapter 15: Glycosylated bioactive compound discovery by from Actinomycetes by combination of genome mining, gene inactivation and activation of silent biosynthetic clusters.
Chapter 16: Genetic engineering for overproducing bioactive secondary metabolites in Actinomycetes
Chapter 17: Transcriptional gene cluster refactoring for increased secondary metabolites production
Chapter 18: Synthetic biology in Actinomycetes for natural product discovery
Chapter 19: Metabolic engineering of antibiotic factories: new tools for antibiotic production in Actinomycetes
Chapter 20: Bioinformatic tools for use in pks and nrps discovery in Actinomycetes.
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