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Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases

Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases

Hardcover

Series: Advances in Experimental Medicine and Biology, Book 863

Medical ReferenceChemistry

ISBN10: 3319183648
ISBN13: 9783319183640
Publisher: Springer Nature
Published: Jul 1 2015
Pages: 163
Weight: 1.14
Height: 0.44 Width: 7.00 Depth: 10.00
Language: English

This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed 'amyloid'. Examples of cerebral amyloid disorders include common neurodegenerative diseases like Alzheimer's disease-related dementia and Parkinson's disease, as well as other less prevalent conditions like Huntington's disease, cerebral amyloid angiopathy and the transmissible prion disorders. A disease-modifying therapeutic agent is still lacking for all these diseases, and there are no approved therapies that target amyloid formation directly. Nevertheless, a large and complex group of natural aromatic compounds known as polyphenols are rapidly emerging as potentially potent anti-amyloidogenic agents.

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