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Nanoscale Imaging of Synapses: New Concepts and Opportunities

Nanoscale Imaging of Synapses: New Concepts and Opportunities

Paperback

Series: Neuromethods, Book 84

Medical ReferenceBiology

ISBN10: 1493949187
ISBN13: 9781493949182
Publisher: Humana Pr
Published: Aug 23 2016
Pages: 231
Weight: 0.95
Height: 0.51 Width: 7.00 Depth: 10.00
Language: English
Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and disease. Because they are very small and highly dynamic, it is very difficult to study them with traditional techniques. Fortunately, recent ground-breaking advances in optical microscopy (e.g. STED, PALM, STORM, SIM) have greatly improved our ability to image living synapses at the nanoscale, even down to the level of single molecules. The proposed volume brings together leading researchers to review these exciting new techniques and their application in neurobiological research. It will explain and discuss the basic principles behind the various superresolution modalities, how they are implemented, what their scope and limitations are etc. In addition, several key research discoveries on synapses enabled by these novel approaches will be highlighted.

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