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Mouse Models of Developmental Genetic Disease: Volume 84

Mouse Models of Developmental Genetic Disease: Volume 84

Hardcover

Series: Current Topics in Developmental Biology, Book 84

Medical ReferenceBiology

ISBN10: 0123744547
ISBN13: 9780123744548
Publisher: Academic Press
Published: Dec 15 2008
Pages: 512
Weight: 2.40
Height: 1.40 Width: 6.10 Depth: 9.00
Language: English
Approximately three percent of newborn humans have congenital anomalies with significant cosmetic and/or functional consequences. Much of our ability to understand what has gone awry in these birth defects rests with development of animal models for them; the mouse has emerged as the model organism of choice for these studies. This volume reviews mouse models of specific developmental genetic diseases, including neural tube defects; cleft lip and/or palate; congenital heart disease; ciliopathies; hereditary deafness and others to provide conceptual insight into congenital anomalies generally. The interplay between clinical observation and murine model systems is expected to yield deep insight into mammalian developmental processes and the emergence of effective preventive and/or therapeutic strategies.

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