Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Methotrexate: Unlocking Photopharmacological Potential

Methotrexate: Unlocking Photopharmacological Potential

Sarkar, Himadri Sekhar

Paperback

Medical Reference

ISBN10: 620677032X
ISBN13: 9786206770329
Publisher: Scholars' Press
Published: Jun 19 2024
Pages: 112
Weight: 0.39
Height: 0.27 Width: 6.00 Depth: 9.00
Language: English
Methotrexate (MTX), an FDA-approved folic acid antagonist, is highly effective in treating rheumatoid arthritis, psoriasis, inflammatory bowel disease, and various cancers, including acute leukemia, head and neck cancer, and osteosarcoma. However, systemic administration of anticancer agents often suffers from off-target effects, impacting efficacy and tolerability. Photopharmacology, which employs photoswitchable drugs, is well-suited for enhancing drug activity. Precise spatiotemporal control reduces off-target effects, allowing higher doses for improved efficacy.This book delves into MTX's historical development and current applications, exploring its potential as a photoswitchable inhibitor for human and E. coli DHFR through a comprehensive structure-based drug discovery approach. It guides readers through methotrexate's evolution, highlighting its role as a pioneer in precision medicine. The book emphasizes the integration of conventional pharmacological principles with innovative photopharmacological strategies, shaping a promising frontier in targeted therapeutic interventions.

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