Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Mathematical Modelling of Molecular Networks in Cancer Cells Using Modular Response Analysis

Mathematical Modelling of Molecular Networks in Cancer Cells Using Modular Response Analysis

Klinger, Bertram

Paperback

BiologyPhysics

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ISBN10: 383254299X
ISBN13: 9783832542993
Publisher: Logos Verlag Berlin
Published: Oct 14 2016
Pages: 177
Weight: 0.45
Height: 0.48 Width: 5.68 Depth: 8.04
Language: English
Cancer emerges from the body's own cells that via mutations have become semi-autonomous with often fatal consequences for the host. To date, 25 % of all death cases in Germany can be attributed to cancer. One reason behind the inability to confine tumours with current therapy approaches resides in the lack of comprehension of the complex molecular changes that occur during malignant transformation. In order to thoroughly study molecular networks in cancer, the mathematical modelling technique Modular Response Analysis was extended for application to various tasks such as network reconstruction, feedback analysis, and hypothesis testing. These analyses enabled to extend the understanding of molecular interactions and to identify a potent combinatorial treatment strategy for a mutation type of cancer previously assumed to be undruggable.

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